User profiles for P. Benjamin Stranges

P Benjamin Stranges

Principal Scientist; GRO Biosciences
Verified email at grobio.com
Cited by 5983

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

P Mali, J Aach, PB Stranges, KM Esvelt… - Nature …, 2013 - nature.com
Prokaryotic type II CRISPR-Cas systems can be adapted to enable targeted genome
modifications across a range of eukaryotes 1 , 2 , 3 , 4 , 5 , 6 , 7 . Here we engineer this system to …

[HTML][HTML] Physical principles for scalable neural recording

…, JI Glaser, D Amodei, PB Stranges… - Frontiers in …, 2013 - frontiersin.org
Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond
resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely …

A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds

PB Stranges, B Kuhlman - Protein Science, 2013 - Wiley Online Library
The accurate design of new protein–protein interactions is a longstanding goal of
computational protein design. However, most computationally designed interfaces fail to form …

Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array

…, M Chien, A Bibillo, PB Stranges… - Proceedings of the …, 2016 - National Acad Sciences
DNA sequencing by synthesis (SBS) offers a robust platform to decipher nucleic acid sequences.
Recently, we reported a single-molecule nanopore-based SBS strategy that accurately …

Community-wide assessment of protein-interface modeling suggests improvements to design methodology

…, J Esquivel-Rodríguez, D Kihara, PB Stranges… - Journal of molecular …, 2011 - Elsevier
The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment
of protein Structure Prediction) experiments have demonstrated the power of community-wide …

[HTML][HTML] A generic program for multistate protein design

A Leaver-Fay, R Jacak, PB Stranges, B Kuhlman - PloS one, 2011 - journals.plos.org
Some protein design tasks cannot be modeled by the traditional single state design strategy
of finding a sequence that is optimal for a single fixed backbone. Such cases require …

Computational design of a symmetric homodimer using β-strand assembly

PB Stranges, M Machius, MJ Miley… - Proceedings of the …, 2011 - National Acad Sciences
Computational design of novel protein–protein interfaces is a test of our understanding of
protein interactions and has the potential to allow modification of cellular physiology. Methods …

Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array

PB Stranges, M Palla, S Kalachikov… - Proceedings of the …, 2016 - National Acad Sciences
Scalable, high-throughput DNA sequencing is a prerequisite for precision medicine and
biomedical research. Recently, we presented a nanopore-based sequencing-by-synthesis (…

Multiplex single-molecule kinetics of nanopore-coupled polymerases

M Palla, S Punthambaker, B Stranges, F Vigneault… - Acs Nano, 2020 - ACS Publications
DNA polymerases have revolutionized the biotechnology field due to their ability to precisely
replicate stored genetic information. Screening variants of these enzymes for specific …

Design of protein-protein interactions via β-strand pairing

PB Stranges - 2012 - search.proquest.com
The design of new protein-protein interfaces is a test of our understanding of protein interaction
biophysics and can provide new tools to understand cell biology. Methods to accurately …