User profiles for P. Benjamin Stranges
P Benjamin StrangesPrincipal Scientist; GRO Biosciences Verified email at grobio.com Cited by 5983 |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prokaryotic type II CRISPR-Cas systems can be adapted to enable targeted genome
modifications across a range of eukaryotes 1 , 2 , 3 , 4 , 5 , 6 , 7 . Here we engineer this system to …
modifications across a range of eukaryotes 1 , 2 , 3 , 4 , 5 , 6 , 7 . Here we engineer this system to …
[HTML][HTML] Physical principles for scalable neural recording
Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond
resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely …
resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely …
A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
PB Stranges, B Kuhlman - Protein Science, 2013 - Wiley Online Library
The accurate design of new protein–protein interactions is a longstanding goal of
computational protein design. However, most computationally designed interfaces fail to form …
computational protein design. However, most computationally designed interfaces fail to form …
Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array
…, M Chien, A Bibillo, PB Stranges… - Proceedings of the …, 2016 - National Acad Sciences
DNA sequencing by synthesis (SBS) offers a robust platform to decipher nucleic acid sequences.
Recently, we reported a single-molecule nanopore-based SBS strategy that accurately …
Recently, we reported a single-molecule nanopore-based SBS strategy that accurately …
Community-wide assessment of protein-interface modeling suggests improvements to design methodology
The CAPRI (Critical Assessment of Predicted Interactions) and CASP (Critical Assessment
of protein Structure Prediction) experiments have demonstrated the power of community-wide …
of protein Structure Prediction) experiments have demonstrated the power of community-wide …
[HTML][HTML] A generic program for multistate protein design
Some protein design tasks cannot be modeled by the traditional single state design strategy
of finding a sequence that is optimal for a single fixed backbone. Such cases require …
of finding a sequence that is optimal for a single fixed backbone. Such cases require …
Computational design of a symmetric homodimer using β-strand assembly
PB Stranges, M Machius, MJ Miley… - Proceedings of the …, 2011 - National Acad Sciences
Computational design of novel protein–protein interfaces is a test of our understanding of
protein interactions and has the potential to allow modification of cellular physiology. Methods …
protein interactions and has the potential to allow modification of cellular physiology. Methods …
Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array
Scalable, high-throughput DNA sequencing is a prerequisite for precision medicine and
biomedical research. Recently, we presented a nanopore-based sequencing-by-synthesis (…
biomedical research. Recently, we presented a nanopore-based sequencing-by-synthesis (…
Multiplex single-molecule kinetics of nanopore-coupled polymerases
DNA polymerases have revolutionized the biotechnology field due to their ability to precisely
replicate stored genetic information. Screening variants of these enzymes for specific …
replicate stored genetic information. Screening variants of these enzymes for specific …
Design of protein-protein interactions via β-strand pairing
PB Stranges - 2012 - search.proquest.com
The design of new protein-protein interfaces is a test of our understanding of protein interaction
biophysics and can provide new tools to understand cell biology. Methods to accurately …
biophysics and can provide new tools to understand cell biology. Methods to accurately …