Liver diseases have become a major health threat across Europe, and the face of European
hepatology is changing due to the cure of viral hepatitis C and the control of chronic viral …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely
underappreciated liver condition which is closely associated with obesity and metabolic …

Health systems have improved their abilities to identify, diagnose, treat and, increasingly,
achieve viral suppression among people living with HIV (PLHIV). Despite these advances, a …

Background: Obesity is associated with increased health risk and has been associated with
alterations in bacterial gut microbiota, with mainly a reduction in Bacteroidetes, but few data …

To investigate the clinical value of somatic TP53 mutations in breast cancer, we assembled
clinical and molecular data on 1,794 women with primary breast cancer with long-term follow-…

We analyzed the serum and cerebrospinal fluid (CSF) leptin secretion and the interaction
between serum leptin and CD4 + CD25 + regulatory T cells (T Regs ) in naïve-to-therapy …

… P < 0.05 and **P < 0.0001 (paired two-tailed Student's t-test (b) or Wilcoxon matched-pairs
test (d… For all analyses, we used two-sided tests, with a P value of <0.05 indicative of statistical …

… Even after multiple adjustment by logistic regression for other variables related to adherence
failure at M20 in univariate analysis (P ≤ 0.25), number of self-reported lipodystrophy-…

… We measured the levels of phosphorylated STAT5 (p-STAT5) upon CD3 and CD28 … We
found reduced activation of STAT5 (as assessed by the amount of p-STAT5) in T reg cells from …

Objectives: Our objective was to describe the evolution of adherence to highly active
antiretroviral therapy (HAART) over a 20-month period and its relationship with virologic success. …