Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β
(Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol …

… ., Marambaud, P. Novel synthetic small-molecule activators of AMPK as enhancers of …
With a molecular weight <500 Da, a log P <5, and <5 H-bond donors and 10 H-bond acceptors (…

… In addition, our results show that the phosphorylation pattern of tau Thr 231 is different from
that of p-Thr 172 AMPK following AICAR treatment. These results suggest that tau Thr 231 …

AMP-activated protein kinase (AMPK) is a sensor and regulator of cellular energy metabolism
potentially Implicated In a broad range of conditions, including obesity and Alzheimer’s …

… the levels of phospho-mTOR (p-mTOR) and phospho-S6 (p-S6) in the liver and retina.
Western blot analyses revealed robust increases in p-mTOR and p-S6 levels in whole-liver …

… P-values were adjusted for multiple testing using the FDR method (77). Heat maps were
constructed with MetaR, using the pheatmap R package. Gene annotations were determined …

… Notably, in BMP9/10-immunoblocked retinas, we found a significant increase in the expression
of Angpt2 (first hit when sorting by adjusted P-values, log2 fold change = 0.71, adjusted P …

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder
characterized by arteriovenous malformations and blood vessel enlargements. However, there are …

Construction of robust and accurate deep neural networks (DNNs) is a computationally
demanding and time-consuming process. Such networks also end up being memory intensive. …

All people with diabetes have the risk of developing diabetic retinopathy (DR), a vision-threatening
complication. Early detection and timely treatment can reduce the occurrence of …