Pro-inflammatory, tumour-promoting and anti-tumour diterpenes of the plant families Euphorbiaceae and Thymelaeaceae
JG Buchanan, P Crews, B Epe, FJ Evans… - Fortschritte der Chemie …, 1983 - Springer
Plants and plant products have been used as drugs for thousands of years and in recent
history have provided a definite stimulus for the development of natural product chemistry. …
history have provided a definite stimulus for the development of natural product chemistry. …
Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants
…, HC Vervoort, K Tenney, RG Linington, P Crews - Bioorganic & medicinal …, 2011 - Elsevier
Coral reefs are among the most productive marine ecosystems and are the source of a
large group of structurally unique biosynthetic products. Annual reviews of marine natural …
large group of structurally unique biosynthetic products. Annual reviews of marine natural …
[HTML][HTML] The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Covering: up to 2018 With contributions from the global natural product (NP) research
community, and continuing the Raw Data Initiative, this review collects a comprehensive …
community, and continuing the Raw Data Initiative, this review collects a comprehensive …
[PDF][PDF] Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
…, YNP Chen, DS France, H Wang, P Crews… - Cancer cell, 2004 - cell.com
Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …
High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin …
…, J Stryker, N Pokala, M Sanders, P Crews… - The Journal of cell …, 1997 - rupress.org
We report that the actin assembly inhibitor latrunculin-A (LAT-A) causes complete disruption
of the yeast actin cytoskeleton within 2–5 min, suggesting that although yeast are nonmotile, …
of the yeast actin cytoskeleton within 2–5 min, suggesting that although yeast are nonmotile, …
Organic structure analysis
P Crews, J Rodriquez, M Jaspars, RJ Crews - 1998 - theaic.org
The Crews text is very useful for a 400-level special topics class, particularly if the pedagogical
style of the professor leans towards inquiry-driven or “flipped classroom” models of …
style of the professor leans towards inquiry-driven or “flipped classroom” models of …
Jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis sp.
P Crews, LV Manes, M Boehler - Tetrahedron letters, 1986 - Elsevier
… Phillip Crews*, Lawrence V. Manes, and Mark Boehler … Par previous papers see:
Manes, LV; Naylor, S.; Crews, P.; Bakus, GJJ Org. Chem. 1985, so, 284, and refs within. …
Manes, LV; Naylor, S.; Crews, P.; Bakus, GJJ Org. Chem. 1985, so, 284, and refs within. …
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting
…, M Platzer, BK Rubio, SJ Robinson, P Crews… - Nature chemical …, 2009 - nature.com
There is increasing evidence that uncultivated bacterial symbionts are the true producers of
numerous bioactive compounds isolated from marine sponges. The localization and …
numerous bioactive compounds isolated from marine sponges. The localization and …
Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase
…, LB Perez, KW Bair, P Crews - The Journal of …, 2003 - ACS Publications
Four novel bisulfide bromotyrosine derivatives, psammaplins E (9), F (10), G (11), and H (12),
and two new bromotyrosine derivatives, psammaplins I (13) and J (14), were isolated from …
and two new bromotyrosine derivatives, psammaplins I (13) and J (14), were isolated from …
Psymberin, A Potent Sponge-Derived Cytotoxin from Psammocinia Distantly Related to the Pederin Family
RH Cichewicz, FA Valeriote, P Crews - Organic letters, 2004 - ACS Publications
Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1)
possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural …
possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural …