Purification and unique properties of mammary epithelial stem cells

J Stingl, P Eirew, I Ricketson, M Shackleton, F Vaillant… - Nature, 2006 - nature.com
… (not significantly different from the observed outcome of 2 per 52 = 0.04, P = 0.19). f, A
mammary gland regenerated in a fat … The goodness of fit of this model was confirmed (P = 0.40). …

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

P Eirew, A Steif, J Khattra, G Ha, D Yap, H Farahani… - Nature, 2015 - nature.com
Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution 1 , 2 , …

Deciphering the mammary epithelial cell hierarchy

J Stingl, A Raouf, P Eirew, CJ Eaves - Cell cycle, 2006 - Taylor & Francis
P. Eirew was a recipient of a Canadian Stem Cell Network Studentship and a Canadian
Imperial Bank of Commerce Breast cancer Interdisciplinary Research fellowship. …

The omics of triple-negative breast cancers

H Xu, P Eirew, SC Mullaly, S Aparicio - Clinical chemistry, 2014 - academic.oup.com
BACKGROUND: Triple-negative breast cancers (TNBC) do not represent a single disease
subgroup and are often aggressive breast cancers with poor prognoses. Unlike estrogen/…

[PDF][PDF] A biobank of breast cancer explants with preserved intra-tumor heterogeneity to screen anticancer compounds

…, SJ Sammut, L Jones, E Provenzano, R Baird, P Eirew… - Cell, 2016 - cell.com
The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured
in pre-clinical models. We have created a large collection of breast cancer patient-derived …

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

P Eirew, J Stingl, A Raouf, G Turashvili, S Aparicio… - Nature medicine, 2008 - nature.com
… Gels were then transplanted under the kidney capsule of immunodeficient mice given
slow-release pellets of human β-estradiol and progesterone (E2 + P). (b) H&E and immunostained …

[HTML][HTML] Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland

…, N Novcic, IA Russell, S Avril, M Prater, P Eirew… - Breast cancer …, 2012 - Springer
… However, these latter observations are not consistent with the results presented here and
by Eirew and colleagues [31] since we observe that the majority of cells with in vivo engrafting …

[HTML][HTML] Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses

…, AW Zhang, F Kabeer, JLP Lim, J Biele, P Eirew… - Genome biology, 2019 - Springer
Background Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex
biological systems, such as tumor heterogeneity and tissue microenvironments. However, …

Clonal fitness inferred from time-series modelling of single-cell cancer genomes

…, N Rusk, TR de Algara, SR Lee, BYC Cheng, P Eirew… - Nature, 2021 - nature.com
Progress in defining genomic fitness landscapes in cancer, especially those defined by copy
number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of …

[HTML][HTML] Single-cell genomic variation induced by mutational processes in cancer

…, H Shi, E Leventhal, T Masud, P Eirew… - Nature, 2022 - nature.com
How cell-to-cell copy number alterations that underpin genomic instability 1 in human
cancers drive genomic and phenotypic variation, and consequently the evolution of cancer 2 , …