… the channel pore (P domain); 2) inward-rectifying channels (Kir) are tetramers of subunits
including only 2 transmembrane segments and one P domain; and 3) two P-domain channels …

… Time to death (min) after ICV injection of 0.1 μL of crude venom in mice (Escoubas,
unpublished data). Y scale to 60 min, some venoms may have longer time to death. Tarantula …

Modern drug discovery is increasingly in need of a novel paradigm to replace the classical
blockbuster-based economic model of large pharmaceutical companies. Loss of patent …

Acid sensing is associated with nociception, taste transduction, and perception of extracellular
pH fluctuations in the brain. Acid sensing is carried out by the simplest class of ligand-…

From a systematic screening of animal venoms, we isolated a new toxin (APETx2) from the
sea anemone Anthopleura elegantissima, which inhibits ASIC3 homomeric channels and …

… Thus, P and G denote Conus purpurascens and Conus geographus, respectively. In cases
where two distinct Conus species names begin with the same letter, additional lowercase …

… In phase II (from 30 to 40 min), the score reduction induced by PcTx1 was even higher
than that induced by morphine (P < 0.05). These three acute pain models are indicative of a …

… the isolation, chemical characterization, biological activity and structures of pandinins 1
and 2, two novel α-helical polycationic antimicrobial peptides from venom of the scorpion P. …

… number of tarantula venoms (Escoubas and Rash, 2004) and similar to the distribution
observed in a number of venoms from several unrelated spider families (Escoubas, unpublished). …

… been used in the isolation of both known and novel chloride channel toxins from other venoms
and for rapid repurification of toxins previously characterized (P. Escoubas, unpublished). …