Huntington's disease (HD) is a monogenic neurodegenerative disease that affects the
efferent neurons of the striatum. The protracted evolution of the pathology over 15 to 20 years, …

… analyses of the HD striatum usually indicate decreased concentrations (as expressed per
mg of protein) of all markers associated with GABAergic neurons (GABA, substance P and …

… [14] Bensadoun JC, Deglon N, Tseng JL, Ridet JL, Zurn AD, Aebischer P. Lentiviral vectors
as a … [112] Déglon N, Hantraye P. Viral vectors as tools to model and treat neurodegenerative …

Huntington's disease is a genetic disease, autosomal and dominant, that induces motor
disorders, an inexorable deterioration of higher brain functions and psychiatric disturbances. At …

… FD uptake after treatment relative to baseline levels (P= 0.06). Qualitatively, three of four
lenti-… uptake (K i value) between the groups just failed to reach statistical significance (P = 0.06). …

Background Parkinson's disease is typically treated with oral dopamine replacement therapies;
however, long-term treatment leads to motor complications and, occasionally, impulse …

… Philippe Hantraye elaborated and analysed the video motor assessments, and participated
in the writing of the paper. Marc Peschanski was the principal investigator of the study and …

Background Although we have shown in three out of five patients with Huntington's disease
that motor and cognitive improvements 2 years after intracerebral fetal neural grafts are …

The amyloid precursor protein (APP) is a transmembrane protein expressed in several cell
types. In the nervous system, APP is expressed by glial and neuronal cells, and several lines …

Astrocytes and microglia become reactive under most brain pathological conditions, making
this neuroinflammation process a surrogate marker of neuronal dysfunction. …