Mitosis is the most dramatic — and potentially dangerous — event in the cell cycle, as sister
chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that …

… Jallepalli1,* 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275
York … We thank P. Campbell and J. Korbel for providing access to the images reproduced in …

Aneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human
cancer for nearly a century 1 ; however, the mechanisms responsible for this abnormality …

… The parameter p 0 describes the probability that the second copy of the TSP gene is lost …
of u + p, where p is the rate of LOH in CIN cells. We expect p to be much greater than u and p 0 . …

Abnormalities of chromosome number are the most common genetic aberrations in cancer.
The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian …

It has been proposed that separase-dependent centriole disengagement at anaphase
licenses centrosomes for duplication in the next cell cycle. Here we test whether such a …

Polo-like kinases (Plks) play crucial roles in mitosis and cell division. Whereas lower
eukaryotes typically contain a single Plk, mammalian cells express several closely related but …

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous
recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to …

Cell division is controlled by cyclin-dependent kinases (CDKs). In metazoans, S phase onset
coincides with activation of Cdk2, whereas Cdk1 triggers mitosis. Both Cdk1 and -2 require …

… There was a significant difference (P<0.02) in the duration of the lesion between subjects
with normal glucose tolerance and subjects with diabetes and insulin resistance. The insulin-…