[HTML][HTML] Asthma: from bronchoconstriction to airways inflammation and remodeling

J Bousquet, PK Jeffery, WW Busse… - American journal of …, 2000 - atsjournals.org
… Epithelial damage may lead to heightened airways responsiveness (125, 126), a failure
to metabolize agonists (127), the destruction of a diffusion barrier altering permeability of …

Remodeling in asthma and chronic obstructive lung disease

PK Jeffery - American journal of respiratory and critical care …, 2001 - atsjournals.org
… Table 3 summarizes what we know about the likely effects of inhaled corticosteroids (PK
Jeffery, unpublished, 2001) and other classes of agent such as long-acting β-agonists and …

Structural and inflammatory changes in COPD: a comparison with asthma

PK Jeffery - Thorax, 1998 - ncbi.nlm.nih.gov
… 83 Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1
… 89 Jeffery PK. Comparative morphology of the airways in asthma and chronic obstructive …

Bronchial biopsies in asthma

PK Jeffery, AJ Wardlaw, FC Nelson, JV Collins… - Am Rev Respir …, 1989 - atsjournals.org
Little is known of the structural changes in mild asthma. We have studied the light and electron
microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from …

Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1.

…, TW Ansari, NC Barnes, PK Jeffery - American journal of …, 1997 - atsjournals.org
In order to determine whether the airway inflammatory cells of chronic obstructive pulmonary
disease (COPD) are different from those seen in asthma, we have studied a subepithelial …

Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma

M Azzawi, B Bradley, PK Jeffery, AJ Frew… - Am Rev Respir …, 1990 - atsjournals.org
p <0.01) or the nonasthmatic atopic control subjects (p < 0.05) (see table 2). In asthma,
eosinophil numbers were increased at airway levels I (p < 0.05) and II (p … airway level II (p < 0.05). …

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

…, BJ Stevenson, X Gao, SR Durham, PK Jeffery… - Nature medicine, 1995 - nature.com
We report the results of a double-blind, placebo-controlled trial in nine cystic fibrosis (CF)
subjects receiving cationic liposome complexed with a complementary DNA encoding the CF …

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

…, SR Durham, JV Collins, PK Jeffery - The Journal of …, 1991 - Am Soc Clin Investig
We have attempted to identify mRNA for IL-5 in endobronchial mucosal biopsies from
asthmatics and controls, using the technique of in situ hybridization. Bronchial biopsies were …

Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study

PK Jeffery, RW Godfrey, E Ädelroth… - American Review of …, 2012 - atsjournals.org
… collagen compared with the healthy control group (p < 0.01). Compared with the control …
(p < 0.01) and eosinophils (p < 0.05) in Group A and of eosinophils (p < 0.01) and histiocytes (p

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy …

…, LB Schwartz, SR Durham, PK Jeffery… - Journal of Allergy and …, 1991 - Elsevier
… + cells in subjects with atopic asthma when these subjects were compared with the healthy
control subjects (p < 0.001, level 1; p < 0.03, level 2) and with atopic subjects without asthma (…