The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

Heat stress is a major threat to cattle reproduction today. It has been shown that the effect of
high temperature not only has a negative effect on the hormonal balance, but also directly …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

… bovine model of reproductive aging - Kordowitzki - 2021 - Aging Cell - Wiley Online Library
… The red dotted line corresponds to a significance threshold of p < 10 −4 . Individual CpGs are …

For many years, vitamin D (VD) has been known to be an essential micronutrient with important
relevance not only for the skeletal system, but also for numerous other mammalian organ …

Research from the past decades provided strong evidence that in humans the pool of
oocytes starts to decline already before the birth of a female individual, and from menarche to …

… We report the meta-analysis P value in the title of the forest plot. (E) Module that correlates
significantly (P < 1 × 10 −300 ) with relative age (defined as ratio of age/maximum life span) …

It is a well-known fact that the reproductive organs in women, especially oocytes, are exposed
to numerous regulatory pathways and environmental stimuli. The maternal age is one …