… kinase (ERK-p) and Akt (Akt-p) in the EGF-induced signaling pathway (32, 33). Using these
models, the authors predicted that the ratio of Akt-p/ERK-p increases in mutants compared …

… Macklin et al 50 and Hyun and Macklin 51 applied a CBM to study oxygen-driven …
Hyun AZ, Macklin P: Improved patient-specific calibration for agent-based cancer modeling. …

The use of artificial intelligence will transform clinical practice over the next decade and the
early impact of this will likely be the integration of image analysis and machine learning into …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation and …

… (see the reviews listed previously and recent work by Macklin and Lowengrub [45–48]). We
… At the necrotic boundary ΣN we assume P is continuous. We assume that no voids form and …

… with probability (26) where p is used as our surrogate marker for immunogenicity (see above),
and r kill is the rate at which adhered immune cells kill tumor cells with p = 1. If they induce …

… tumor cells prefer to stay bonded with each other rather than being in any other configuration,
that the cell density is roughly constant and that there is only isotropic stress (pressure p), …

… For simplicity, we model α P as constant for and specific to each cell type. In Macklin et al.
(2010b), we discuss how to incorporate • (ie, a cell's internal protein expression) and ○ (as …

In this paper, we present and investigate a model for solid tumor growth that incorporates
features of the tumor microenvironment. Using analysis and nonlinear numerical simulations, …

The collection of microbes that live in and on the human body – the human microbiome –
can impact on cancer initiation, progression, and response to therapy, including cancer …