User profiles for P. McGowan
 | Patrick McGowanProfessor of Biological Sciences, University of Toronto Verified email at utoronto.ca Cited by 9383 |
Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development
…, SP Marsden, AJ Blacker, PC McGowan - Chemical Society …, 2014 - pubs.rsc.org
Cu-catalysed arylation reactions devoted to the formation of C–C and C–heteroatom bonds (Ullmann-type
couplings) have acquired great importance in the last decade. This review …
couplings) have acquired great importance in the last decade. This review …
The social environment and the epigenome
The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
The epigenetics of social adversity in early life: implications for mental health outcomes
PO McGowan, M Szyf - Neurobiology of disease, 2010 - Elsevier
An organism's behavioral and physiological and social milieu influence and are influenced
by the epigenome, which is composed predominantly of chromatin and the covalent …
by the epigenome, which is composed predominantly of chromatin and the covalent …
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
PO McGowan, A Sasaki, AC D'alessio, S Dymov… - Nature …, 2009 - nature.com
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
…, I Hellström, KE Hellström, JA Ledbetter, P McGowan… - Cell, 1992 - cell.com
Interaction of the B7 molecule on antigen-presenting cells with its receptors CD28 and CTLA-4
on T cells provides costimulatory signals for T cell activation. We have studied the effects …
on T cells provides costimulatory signals for T cell activation. We have studied the effects …
Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.
L Chen, P McGowan, S Ashe, J Johnston, Y Li… - The Journal of …, 1994 - rupress.org
A costimulatory signal through B7 to its counter-receptor CD28 on T cells enhances T cell
activation. We have generated recombinant retroviruses containing cDNA for murine B7 and …
activation. We have generated recombinant retroviruses containing cDNA for murine B7 and …
[HTML][HTML] Broad epigenetic signature of maternal care in the brain of adult rats
Background Maternal care is associated with long-term effects on behavior and epigenetic
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …
[PDF][PDF] Implementation and quantitative evaluation of chronic disease self-management programme in Shanghai, China: randomized controlled trial
D Fu, H Fu, P McGowan, Y Shen, L Zhu… - Bulletin of the World …, 2003 - SciELO Public Health
OBJECTIVE: To evaluate the effectiveness of the Shanghai Chronic Disease Self-Management
Program (CDSMP). METHODS: A randomized controlled trial with six-month follow-up …
Program (CDSMP). METHODS: A randomized controlled trial with six-month follow-up …
African military coups d'état, 1956–2001: frequency, trends and distribution
PJ McGowan - The Journal of Modern African Studies, 2003 - cambridge.org
Described here is a new data set including all successful coups d'état (80), failed coup
attempts (108) and reported coup plots (139) for all 48 independent sub-Saharan African (SSA) …
attempts (108) and reported coup plots (139) for all 48 independent sub-Saharan African (SSA) …
[HTML][HTML] Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
PO McGowan, A Sasaki, TCT Huang, A Unterberger… - PloS one, 2008 - journals.plos.org
Background Alterations in gene expression in the suicide brain have been reported and for
several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA …
several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA …