Background Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a
genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four …

… Thus, our primary analysis is based on unadjusted P … of P < 1 × 10 −5 and P < 5 × 10 −7
as moderately strong and strong evidence for association, respectively 4 . Loci (n = 12) with P < …

The density of striatal dopamine D2 receptors has been shown to vary considerably among
healthy subjects. 1 This variability might be due to genetic or environmental factors. In the …

… The six potential transmembrane-spanning regions and the P putative pore region are
shaded and underlined. Pluses indicate homology between the aligned amino acids. The …

The genetic basis of bipolar disorder has long been thought to be complex, with the potential
involvement of multiple genes, but methods to analyze populations with respect to this …

… Constructs with 3a, 4 and 5 repeats were significantly more active than constructs containing
3 repeats (***P < 0.0001, one way ANOVA followed by Fisher's protected least significant …

Epilepsy affects at least 2% of the population at some time in their lives 1 . The epilepsies
are a heterogeneous group of disorders, many with an inherited component 2 . Although …

… cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, …
/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = …

… To achieve genome-wide significance, P values have to pass a stringent threshold. It is …
GWAS typically yield many more associations with small P values than expected by chance. This …

… /P sample of 462 unrelated cases and 954 controls. In the entire sample, the most significant
SNP (rs987525) had a P … this study has identified a major susceptibility locus for NSCL/P. …