User profiles for P. Rakic

Pasko Rakic

Yale University
Verified email at yale.edu
Cited by 96399

Specification of cerebral cortical areas

P Rakic - Science, 1988 - science.org
How the immense population of neurons that constitute the human cerebral neocortex is
generated from progenitors lining the cerebral ventricle and then distributed to appropriate …

A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution

P Rakic - Trends in neurosciences, 1995 - cell.com
… Pasko Rakic is at by which the neocortex expanded in surface area during … /ayers, they
settle at the interface between the developing cortical p/ate (CP) and the marginal zone (MZ) ond, …

Evolution of the neocortex: a perspective from developmental biology

P Rakic - Nature Reviews Neuroscience, 2009 - nature.com
The enlargement and species-specific elaboration of the cerebral neocortex during evolution
holds the secret to the mental abilities of humans; however, the genetic origin and cellular …

Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex

P Rakic, JP Bourgeois, MF Eckenhoff, N Zecevic… - Science, 1986 - science.org
… 26 synapses per 100 p.m2 inthe prefrontal cortex (Fig. 2C) to 34 synapses per 100 p.m2 in …
The value of 15 to 20 synapses per 100 p.m2 of neuropil may be structurally, metabolically, or …

Mode of cell migration to the superficial layers of fetal monkey neocortex

P Rakic - Journal of Comparative Neurology, 1972 - Wiley Online Library
… The leading processes, 50 to 70 p long, are irregular cytoplasmic cylinders containing
prominent … Throughout the 3500 p pathway across the intermediate zone the migrating cells are …

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

…, S Na, CY Kuan, D Yang, H Karasuyama, P Rakic… - Nature, 1996 - nature.com
PROGRAMMED cell death (apoptosis) is a prominent feature of the development of the
immune and nervous systems 1,2 . The identification of the Caenorhabditis elegans cell death …

[HTML][HTML] Reduced apoptosis and cytochrome c–mediated caspase activation in mice lacking caspase 9

…, Y Gu, C Taya, H Karasuyama, MSS Su, P Rakic… - Cell, 1998 - cell.com
Caspases are essential components of the mammalian cell death machinery. Here we test
the hypothesis that Caspase 9 (Casp9) is a critical upstream activator of caspases through …

Synaptogenesis in the prefrontal cortex of rhesus monkeys

JP Bourgeois, PS Goldman-Rakic, P Rakic - Cerebral cortex, 1994 - academic.oup.com
… E59and E104, coinciding with the completion of cortical neurogenesis and cell migration (P. …
the plate (Goldman-Rakic, 1981; Schwartz and Goldman-Rakic, 1991). Anterograde tracing …

Modulation of neuronal migration by NMDA receptors

H Komuro, P Rakic - Science, 1993 - science.org
p-chloromercuriphenylsulfonic acid (p-CMPS), which inhibits glutamate uptake by astrocytes
(19). The addition of 10 to 30 pM p-… However, the addition of 100 [tM p-CMPS significantly …

Neuron‐glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electonmicroscopic study in Macacus rhesus

P Rakic - Journal of Comparative Neurology, 1971 - Wiley Online Library
… , ’66; Rakic, ’70). While studying development of the human cerebellar cortex (Rakic and
Sidman, … Rakic, P. Golgi and electronmicroscopic cytology of migrating granule cells during late …