Increased number of islet-associated macrophages in type 2 diabetes
… P < 0.05 by Student's t test or ANOVA with Dunnett's post hoc … P < 0.05 by Student's t test or
ANOVA with Dunnett's post hoc … P < 0.05 by Student's t test or ANOVA with Dunnett's post hoc …
ANOVA with Dunnett's post hoc … P < 0.05 by Student's t test or ANOVA with Dunnett's post hoc …
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
… We identified the LATS1 mutation encoding p.Arg995Cys as being significant in the SRM
analysis (… We assessed the effects of the LATS1 p.Arg995Cys substitution with in silico protein …
analysis (… We assessed the effects of the LATS1 p.Arg995Cys substitution with in silico protein …
Chromatin three-dimensional interactions mediate genetic effects on gene expression
…, P Ribaux, M Wiederkehr, E Falconnet, P Bucher… - Science, 2019 - science.org
INTRODUCTION Genome-wide studies on the genetic basis of gene expression have advanced
considerably our understanding of the function of the human genome. Large collections …
considerably our understanding of the function of the human genome. Large collections …
[PDF][PDF] CXCL10 impairs β cell function and viability in diabetes through TLR4 signaling
FT Schulthess, F Paroni, NS Sauter, L Shu, P Ribaux… - Cell metabolism, 2009 - cell.com
… p < 0.05 relative to islets cultured at 5.5 mM glucose alone; +p < 0.05 relative to islets in the
absence of Wortmannin at the same CXCL10 concentration. (D–G) Western blot analysis of …
absence of Wortmannin at the same CXCL10 concentration. (D–G) Western blot analysis of …
[PDF][PDF] Biased allelic expression in human primary fibroblast single cells
…, P Ribaux, M Guipponi, I Padioleau, P Carninci… - The American Journal of …, 2015 - cell.com
The study of gene expression in mammalian single cells via genomic technologies now
provides the possibility to investigate the patterns of allelic gene expression. We used single-cell …
provides the possibility to investigate the patterns of allelic gene expression. We used single-cell …
Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts
…, X Blanc, E Falconnet, P Ribaux… - Proceedings of the …, 2018 - National Acad Sciences
… The result of LASSO regression indicates that the cell cycle impacts IS (P = 6.33E-5) more
significantly than XIST (P = 0.0018). To validate this observation, we inferred the directionality …
significantly than XIST (P = 0.0018). To validate this observation, we inferred the directionality …
[HTML][HTML] Activation of NF-κB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells
…, K Rickenbach, G Parnaud, P Ribaux… - Journal of Biological …, 2005 - ASBMB
… p < 0.05 relative to pLL (n = 4), with a minimum of 100 beta cells … p < 0.05 relative to pLL at
respective time point (n = 3). … p < 0.05; ** , p < 0.005 relative to pLL at the respective time point …
respective time point (n = 3). … p < 0.05; ** , p < 0.005 relative to pLL at the respective time point …
[PDF][PDF] Detection of imprinted genes by single-cell allele-specific gene expression
…, G Stamoulis, M Garieri, E Falconnet, P Ribaux… - The American Journal of …, 2017 - cell.com
… In our dataset, this corresponds to a nominal p-value of 0.0035 as calculated considering
our p-value distribution with the R package qvalue (Figure S2A). In Figure S2B we report the …
our p-value distribution with the R package qvalue (Figure S2A). In Figure S2B we report the …
[HTML][HTML] Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations
…, M Garieri, F Santoni, E Falconnet, P Ribaux… - Nature …, 2014 - nature.com
… RAS mutations are almost completely mutually exclusive with JAK2 mutations (P=0.016),
driving a combined total of two-thirds of analysed cases. Clonal architecture analysis reveals …
driving a combined total of two-thirds of analysed cases. Clonal architecture analysis reveals …
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic β-cells
K Bouzakri, P Ribaux, A Tomas, G Parnaud… - Diabetes, 2008 - Am Diabetes Assoc
… was evaluated using ANOVA with post hoc adjustment with P < 0.05 considered significant.
… P < 0.05 vs. basal secretion in cells transfected with scrambled siRNA; #P < 0.05 vs. …
… P < 0.05 vs. basal secretion in cells transfected with scrambled siRNA; #P < 0.05 vs. …