Sex determination offers an opportunity to address many classic questions of developmental
biology. In addition, because sex determination evolves rapidly, it offers an opportunity to …

Insulators play a central role in subdividing the chromosome into a series of discrete
topologically independent domains and in ensuring that enhancers and silencers contact their …

… Using P-mediated transformation we obtained about ten independent transgenic lines for
each construct. We determined that the insert in each line was intact by genomic Southern …

The RNA-induced silencing complex (RISC) or the RISC complex mediates RNAi and is
comprised of proteins belonging to the dicer and Argonaute family proteins. Here we show that …

… Samuels, T Cline, and P. Schedl, unpublished data) have shown that Sxl encodes multiple
size classes of transcripts in females and males, this mode of on/off regulation is general-we …

… Transgenic lines for this construct were then examined for P-galactosidase activity. Like
scs, scs' blocks the yp-1 enhancer, as evidenced by little or no 3-galactosidase in the fat body …

… with a cloned P element probe showed that all three alleles contained P elements at po… ,
arm 183, and screened with a P element probe. P-element-positive clones were isolated and …

… Bob Riggleman,’ Paul Schedl, and Eric Wieschaus Department of Molecular Biology …
associated with the plasma membrane in virtually ail cell types and often coiocalizes with P-actin. …

… The hsp70-Sxl fusion gene, SxlcFI (Figure 1 A), was introduced into the germline by P …
We thank Daniel Bopp for providing the Sxl antibodies and members of the Cline, Schedl, and …

The orb gene of Drosophila encodes sex-specific germ-line proteins that contain two RRM-type
RNA-binding domains. Here we report the distribution of Orb protein in wild-type, …