User profiles for P. Spellman

Paul Spellman

University of California Los Angeles
Verified email at mednet.ucla.edu
Cited by 153320

[HTML][HTML] The somatic genomic landscape of glioblastoma

…, R Gibbs, M Marra, GB Mills, E Lander, P Spellman… - cell, 2013 - cell.com
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

…, P Hingamp, J Quackenbush, G Sherlock, P Spellman… - Nature …, 2001 - nature.com
Microarray analysis has become a widely used tool for the generation of gene expression data
on a genomic scale. Although many significant results have been derived from microarray …

[PDF][PDF] Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

…, JN Sarkaria, C Brennan, A Kahn, PT Spellman… - Cancer cell, 2010 - cell.com
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …

[PDF][PDF] The immune landscape of cancer

…, J Wang, H Zhang, P Anur, M Peto, P Spellman… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

Cluster analysis and display of genome-wide expression patterns

MB Eisen, PT Spellman, PO Brown… - Proceedings of the …, 1998 - National Acad Sciences
A system of cluster analysis for genome-wide expression data from DNA microarray
hybridization is described that uses standard statistical algorithms to arrange genes according to …

Genomic expression programs in the response of yeast cells to environmental changes

AP Gasch, PT Spellman, CM Kao… - Molecular biology of …, 2000 - Am Soc Cell Biol
We explored genomic expression patterns in the yeastSaccharomyces cerevisiae responding
to diverse environmental transitions. DNA microarrays were used to measure changes in …

Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization

PT Spellman, G Sherlock, MQ Zhang… - Molecular biology of …, 1998 - Am Soc Cell Biol
We sought to create a comprehensive catalog of yeast genes whose transcript levels vary
periodically within the cell cycle. To this end, we used DNA microarrays and samples from …

[PDF][PDF] Oncogenic signaling pathways in the cancer genome atlas

…, BS Taylor, J Wang, P Anur, M Peto, P Spellman… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, J Wang, H Zhang, P Anur, M Peto, P Spellman… - Cell, 2018 - cell.com
… ERÀ tumors when using PFI (p = 0.005) and DFI (p = 0.001) as clinical endpoints, but there
was no sufficient evidence of a difference when using OS as the endpoint (p = 0.097). We …

Systematic variation in gene expression patterns in human cancer cell lines

…, U Scherf, MB Eisen, CM Perou, C Rees, P Spellman… - Nature …, 2000 - nature.com
We used cDNA microarrays to explore the variation in expression of approximately 8,000
unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-…