User profiles for P. Spellman
Paul SpellmanUniversity of California Los Angeles Verified email at mednet.ucla.edu Cited by 153320 |
[HTML][HTML] The somatic genomic landscape of glioblastoma
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
Minimum information about a microarray experiment (MIAME)—toward standards for microarray data
Microarray analysis has become a widely used tool for the generation of gene expression data
on a genomic scale. Although many significant results have been derived from microarray …
on a genomic scale. Although many significant results have been derived from microarray …
[PDF][PDF] Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …
[PDF][PDF] The immune landscape of cancer
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
Cluster analysis and display of genome-wide expression patterns
A system of cluster analysis for genome-wide expression data from DNA microarray
hybridization is described that uses standard statistical algorithms to arrange genes according to …
hybridization is described that uses standard statistical algorithms to arrange genes according to …
Genomic expression programs in the response of yeast cells to environmental changes
AP Gasch, PT Spellman, CM Kao… - Molecular biology of …, 2000 - Am Soc Cell Biol
We explored genomic expression patterns in the yeastSaccharomyces cerevisiae responding
to diverse environmental transitions. DNA microarrays were used to measure changes in …
to diverse environmental transitions. DNA microarrays were used to measure changes in …
Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization
We sought to create a comprehensive catalog of yeast genes whose transcript levels vary
periodically within the cell cycle. To this end, we used DNA microarrays and samples from …
periodically within the cell cycle. To this end, we used DNA microarrays and samples from …
[PDF][PDF] Oncogenic signaling pathways in the cancer genome atlas
…, BS Taylor, J Wang, P Anur, M Peto, P Spellman… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…
[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
… ERÀ tumors when using PFI (p = 0.005) and DFI (p = 0.001) as clinical endpoints, but there
was no sufficient evidence of a difference when using OS as the endpoint (p = 0.097). We …
was no sufficient evidence of a difference when using OS as the endpoint (p = 0.097). We …
Systematic variation in gene expression patterns in human cancer cell lines
We used cDNA microarrays to explore the variation in expression of approximately 8,000
unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-…
unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-…