Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA…

Genome is a complex hierarchical structure, and its spatial organization plays an important
role in its function. Chromatin loops and topological domains form the basic structural units of …

It has been established that OMEGA-3 polyunsaturated fatty acids (PUFAs) may improve
lipid and glucose homeostasis and prevent the “low-grade” state of inflammation in animals. …

… Genomic distance w p between two anchors of a loop (subloop) is translated to physical
distance d p between the corresponding beads. During the simulation, the angles α i between …

… pair and recording the minimal p value among all pairs. Adjusted p values were calculated
for each gene by dividing the ranks of the observed p values in the list of p values obtained in …

Recent advances in high-throughput chromosome conformation capture (3C) technology,
such as Hi-C and ChIA-PET, have demonstrated the importance of 3D genome organization in …

Structural variants (SVs) that alter DNA sequence emerge as a driving force involved in the
reorganisation of DNA spatial folding, thus affecting gene transcription. In this work, we …

Background Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion
protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms …

Bots in Real Time Strategy games often play according to predefined scripts, which usually
makes their behaviour repetitive and predictable. In this chapter, we discuss a notion of …

… Przemysław Szałaj presented 3D-NOME, a new computational method for modelling the
three-dimensional structure of the genome [12]. Based on both ChIA-PET data and known …