… P=0.001, global P=0.01). Additional haplotype analyses produced support for association
(P<0.0001, global P… Moreover, this haplotype resembles that investigated by Zill et al. Although …

… Removing these restrictions turned out not to alter our conclusions, with P values changing
only minimally. For the analysis of the LD pattern and haplotype block delineation, we used …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Tryptophan hydroxylase (TPH), being the rate-limiting enzyme in the biosynthesis of serotonin
plays a major role as candidate gene in several psychiatric disorders. Recently, a second …

… P values were depicted in a quantile-quantile plot (Figure 1). We observed good adherence
of P … by an inflation of highly significant P values were successfully removed by the QC …

We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American
(AA) populations, with replication in independent samples of EAs, AAs and Germans. …

… P values are shown with intracranial content as a cofactor in the analysis of covariance. For
… Results Patients had significantly smaller hippocampal volumes compared with controls (P = .…

… between one single nucleotide polymorphism (p = .004, global p = .01) and suicide. Additionally,
haplotype analysis also produced support for association (p < .0001, global p = .0001). …

Dysregulation of brain serotonin transmission is an important contributing factor in many
psychiatric disorders. Tryptophan hydroxylase (TPH), the rate limiting enzyme in the …

Gamma-aminobutyric acid (GABA) A receptors are believed to mediate some of the physiological
and behavioral actions of ethanol. Recent studies have suggested that genetic variants …