The success of the sterile insect technique (SIT) and other genetic strategies designed to
eliminate large populations of insects relies on the efficient inundative releases of competitive, …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Genetic methods of manipulating or eradicating disease vector populations have long been
discussed as an attractive alternative to existing control measures because of their potential …

Major efforts are currently underway to develop novel, complementary methods to combat
mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an …

We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked
Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying …

Genetic control aims to reduce the ability of insect pest populations to cause harm via the
release of modified insects. One strategy is to bias the reproductive sex ratio towards males so …

Homing endonuclease genes (HEGs) are ‘selfish’ genetic elements that combine the capability
to selectively disrupt specific gene sequences with the ability to rapidly spread from a few …

Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread
a desired allele through a population, have the potential to transform the way societies …

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved
regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (…

Y chromosomes control essential male functions in many species, including sex determination
and fertility. However, because of obstacles posed by repeat-rich heterochromatin, …