Purpose: To determine the prevalence of lupus anticoagulant and anticardiolipin in
systemic lupus erythematosus (SLE) and in non-SLE disorders, and to evaluate the clinical …

The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular
signals required for T cell development, repertoire selection and effector responses to …

Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of
conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant subunits. …

… ; the shaded region represents staining with goat anti-rat immunoglobulin-PE … (GaR)-PE.
The shaded area represents staining of activated cells with GaR alone. After 3 days, most B …

Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator
of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of …

… (B) Column 1: thymocytes from LAT +/− , LAT −/− , and RAG-2 −/− mice were stained with
anti-CD44-FITC, anti-CD25-PE, and a mixture of Quantum red–conjugated anti-CD3, anti-CD4, …

Although ribonucleases H (RNases H) have long been implicated in DNA metabolism, they
are not required for viability in prokaryotes or unicellular eukaryotes. We generated Rnaseh1 …

… The phenotype of thymocytes and peripheral T cells was analyzed by staining with PE-labeled
anti-CD4, CyChrome-labeled anti-CD8α, and FITC-labeled anti-HY clonotypic receptor (…

The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement of T cells. LAT is also expressed in platelets, NK, and mast cells. Although LAT-…

Signals transduced by T cell antigen receptors (TCRs) have been shown to be critical for αβ
and γδ T cell development, but their role in lineage determination remains poorly defined. …