User profiles for P.H. Janak

patricia janak

Bloomberg Distinguished Professor, Johns Hopkins University
Verified email at jhu.edu
Cited by 15199

From circuits to behaviour in the amygdala

PH Janak, KM Tye - Nature, 2015 - nature.com
The amygdala has long been associated with emotion and motivation, playing an essential
part in processing both fearful and rewarding environmental stimuli. How can a single …

[PDF][PDF] Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry

R Keiflin, PH Janak - Neuron, 2015 - cell.com
Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a
fundamental parameter in associative learning models. This RPE hypothesis provides a …

Optogenetics: 10 years after ChR2 in neurons—views from the community

…, JR Huguenard, TR Insel, PH Janak… - Nature …, 2015 - nature.com
… Patricia Janak Patricia Janak: Optogenetics has vastly increased the precision with which
systems neuroscientists can make causal connections between a given circuit and a given …

A causal link between prediction errors, dopamine neurons and learning

…, JR Boivin, IB Witten, K Deisseroth, PH Janak - Nature …, 2013 - nature.com
Situations in which rewards are unexpectedly obtained or withheld represent opportunities
for new learning. Often, this learning includes identifying cues that predict reward availability. …

[PDF][PDF] Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement

…, C Ramakrishnan, GD Stuber, KM Tye, PH Janak… - Neuron, 2011 - cell.com
Currently there is no general approach for achieving specific optogenetic control of genetically
defined cell types in rats, which provide a powerful experimental system for numerous …

Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum

LH Corbit, H Nie, PH Janak - Biological psychiatry, 2012 - Elsevier
BACKGROUND: Addictions are defined by a loss of flexible control over behavior. The
development of response habits might reflect early changes in behavioral control. The following …

Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties

…, JM Richard, EB Margolis, PH Janak - Nature neuroscience, 2018 - nature.com
Environmental cues, through Pavlovian learning, become conditioned stimuli that guide animals
toward the acquisition of rewards (for example, food) that are necessary for survival. We …

General and outcome‐specific forms of Pavlovian‐instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area

LH Corbit, PH Janak… - European Journal of …, 2007 - Wiley Online Library
This study compared the contribution of the general activating and specific cueing properties
of Pavlovian stimuli to Pavlovian‐instrumental transfer (PIT) and the role of the ventral …

RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction

…, K Luong, V Kharazia, PH Janak… - Journal of …, 2004 - Soc Neuroscience
Alcoholism is a devastating disease that manifests as uncontrolled drinking. Consumption
of alcohol is regulated by neurochemical systems within specific neural circuits, but …

Rapid strengthening of thalamo-amygdala synapses mediates cue–reward learning

KM Tye, GD Stuber, B De Ridder, A Bonci, PH Janak - Nature, 2008 - nature.com
What neural changes underlie individual differences in goal-directed learning? The lateral
amygdala (LA) is important for assigning emotional and motivational significance to discrete …