User profiles for P.T. Leftwich
Philip LeftwichUniversity of East Anglia Verified email at uea.ac.uk Cited by 789 |
Evolutionary biology and genetic techniques for insect control
PT Leftwich, M Bolton, T Chapman - Evolutionary Applications, 2016 - Wiley Online Library
The requirement to develop new techniques for insect control that minimize negative
environmental impacts has never been more pressing. Here we discuss population suppression …
environmental impacts has never been more pressing. Here we discuss population suppression …
Transmission efficiency drives host–microbe associations
PT Leftwich, MP Edgington… - Proceedings of the …, 2020 - royalsocietypublishing.org
Sequencing technologies have fuelled a rapid rise in descriptions of microbial communities
associated with hosts, but what is often harder to ascertain is the evolutionary significance of …
associated with hosts, but what is often harder to ascertain is the evolutionary significance of …
Recent advances in threshold-dependent gene drives for mosquitoes
PT Leftwich, MP Edgington… - Biochemical Society …, 2018 - portlandpress.com
Mosquito-borne diseases, such as malaria, dengue and chikungunya, cause morbidity and
mortality around the world. Recent advances in gene drives have produced control methods …
mortality around the world. Recent advances in gene drives have produced control methods …
[HTML][HTML] CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
…, EM Okamoto, DK Purusothaman, PT Leftwich… - Nature …, 2023 - nature.com
Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …
Genetic elimination of field-cage populations of Mediterranean fruit flies
PT Leftwich, M Koukidou… - … of the Royal …, 2014 - royalsocietypublishing.org
The Mediterranean fruit fly (medfly, Ceratitis capitata Wiedemann) is a pest of over 300 fruits,
vegetables and nuts. The sterile insect technique (SIT) is a control measure used to reduce …
vegetables and nuts. The sterile insect technique (SIT) is a control measure used to reduce …
Gut microbiomes and reproductive isolation in Drosophila
PT Leftwich, NVE Clarke… - Proceedings of the …, 2017 - National Acad Sciences
Experimental studies of the evolution of reproductive isolation (RI) in real time are a powerful
way in which to reveal fundamental, early processes that initiate divergence. In a classic …
way in which to reveal fundamental, early processes that initiate divergence. In a classic …
Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella
…, CM Reitmayer, E Lovett, PT Leftwich… - The CRISPR …, 2022 - liebertpub.com
Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …
[HTML][HTML] Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata
…, JD Fawcett, A Siddall, PT Leftwich… - Nature …, 2024 - nature.com
Homing-based gene drives are recently proposed interventions promising the area-wide,
species-specific genetic control of harmful insect populations. Here we characterise a first set …
species-specific genetic control of harmful insect populations. Here we characterise a first set …
Genetic pest management and the background genetics of release strains
PT Leftwich, LG Spurgin… - … of the Royal …, 2021 - royalsocietypublishing.org
Genetic pest management (GPM) methods involve releasing modified versions of a pest
species to mate with wild pests in the target area. Proposed for a wide range of applications in …
species to mate with wild pests in the target area. Proposed for a wide range of applications in …
[HTML][HTML] Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression
Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses
chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The …
chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The …