User profiles for P.T. Leftwich

Philip Leftwich

University of East Anglia
Verified email at uea.ac.uk
Cited by 789

Evolutionary biology and genetic techniques for insect control

PT Leftwich, M Bolton, T Chapman - Evolutionary Applications, 2016 - Wiley Online Library
The requirement to develop new techniques for insect control that minimize negative
environmental impacts has never been more pressing. Here we discuss population suppression …

Transmission efficiency drives host–microbe associations

PT Leftwich, MP Edgington… - Proceedings of the …, 2020 - royalsocietypublishing.org
Sequencing technologies have fuelled a rapid rise in descriptions of microbial communities
associated with hosts, but what is often harder to ascertain is the evolutionary significance of …

Recent advances in threshold-dependent gene drives for mosquitoes

PT Leftwich, MP Edgington… - Biochemical Society …, 2018 - portlandpress.com
Mosquito-borne diseases, such as malaria, dengue and chikungunya, cause morbidity and
mortality around the world. Recent advances in gene drives have produced control methods …

[HTML][HTML] CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus

…, EM Okamoto, DK Purusothaman, PT Leftwich… - Nature …, 2023 - nature.com
Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases
including West Nile virus and lymphatic filariasis, and transmit pathogens threatening …

Genetic elimination of field-cage populations of Mediterranean fruit flies

PT Leftwich, M Koukidou… - … of the Royal …, 2014 - royalsocietypublishing.org
The Mediterranean fruit fly (medfly, Ceratitis capitata Wiedemann) is a pest of over 300 fruits,
vegetables and nuts. The sterile insect technique (SIT) is a control measure used to reduce …

Gut microbiomes and reproductive isolation in Drosophila

PT Leftwich, NVE Clarke… - Proceedings of the …, 2017 - National Acad Sciences
Experimental studies of the evolution of reproductive isolation (RI) in real time are a powerful
way in which to reveal fundamental, early processes that initiate divergence. In a classic …

Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella

…, CM Reitmayer, E Lovett, PT Leftwich… - The CRISPR …, 2022 - liebertpub.com
Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …

[HTML][HTML] Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata

…, JD Fawcett, A Siddall, PT Leftwich… - Nature …, 2024 - nature.com
Homing-based gene drives are recently proposed interventions promising the area-wide,
species-specific genetic control of harmful insect populations. Here we characterise a first set …

Genetic pest management and the background genetics of release strains

PT Leftwich, LG Spurgin… - … of the Royal …, 2021 - royalsocietypublishing.org
Genetic pest management (GPM) methods involve releasing modified versions of a pest
species to mate with wild pests in the target area. Proposed for a wide range of applications in …

[HTML][HTML] Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression

…, SAN Verkuijl, J Purcell, A Merits, PT Leftwich… - Communications …, 2020 - nature.com
Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses
chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The …