Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

…, BEP Henderson, PA Louwe… - European heart …, 2019 - academic.oup.com
Aims A better understanding of the pathways that regulate regeneration of the coronary
vasculature is of fundamental importance for the advancement of strategies to treat patients with …

[HTML][HTML] Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

PA Louwe, L Badiola Gomez, H Webster… - Nature …, 2021 - nature.com
Inflammation generally leads to recruitment of monocyte-derived macrophages. What
regulates the fate of these cells and to what extent they can assume the identity and function of …

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

…, DA Gibson, NJ Steers, K Boufea, PA Louwe… - Science …, 2020 - science.org
Macrophages reside in the body cavities where they maintain serosal homeostasis and
provide immune surveillance. Peritoneal macrophages are implicated in the etiology of …

[HTML][HTML] Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system

…, K Grabert, CC Bain, GM Davis, PA Louwe… - The Journal of …, 2018 - journals.aai.org
CSF1 is the primary growth factor controlling macrophage numbers, but whether expression
of the CSF1 receptor differs between discrete populations of mononuclear phagocytes …

Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum

PA Louwe, SJ Forbes, C Bénézech, C Pridans… - …, 2022 - Wiley Online Library
The relationship between macrophages of the peritoneal cavity and the adjacent omentum
remains poorly understood. Here, we describe two populations of omental macrophages …

CD11c identifies microbiota and EGR2‐dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice

CC Bain, PA Louwe, NJ Steers… - European journal of …, 2022 - Wiley Online Library
The murine serous cavities contain a rare and enigmatic population of short‐lived F4/80 lo
MHCII + macrophages but what regulates their development, survival, and fate is unclear. …

Welcoming c-MAF to the macrophage transcription factor VAM-ily

PA Louwe, CL Scott - Science Immunology, 2021 - science.org
The transcription factor c-MAF regulates perivascular macrophage phenotypes across
tissues, including white adipose tissue, where its loss from murine vasculature–associated …

Macrophage superclusters to the rescue

PA Louwe, M Guilliams - Science, 2023 - science.org
Positioned at the interface between intestinal and systemic circulation, the liver protects
against blood-borne infections ( 1 , 2 ). To do this, the liver uses a dense network of sinusoids—…

Studying Macrophages in the Murine Steatotic Liver Using Flow Cytometry and Confocal Microscopy

Z Liu, PA Louwe, CL Scott - Tissue-Resident Macrophages: Methods and …, 2023 - Springer
The study of macrophage functions in the context of metabolic dysfunction-associated steatotic
liver disease (MASLD) and metabolic dysfunction associated steatohepatitis (MASH) has …

[HTML][HTML] Systemic influences of mammary cancer on monocytes in mice

A Robinson, M Burgess, S Webb, PA Louwe, Z Ouyang… - Cancers, 2022 - mdpi.com
Simple Summary Using a mouse model of breast cancer driven by the mammary epithelial
expression of the polyoma middle T oncoprotein in which the tumors progress from benign to …