Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction
…, BEP Henderson, PA Louwe… - European heart …, 2019 - academic.oup.com
Aims A better understanding of the pathways that regulate regeneration of the coronary
vasculature is of fundamental importance for the advancement of strategies to treat patients with …
vasculature is of fundamental importance for the advancement of strategies to treat patients with …
[HTML][HTML] Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
PA Louwe, L Badiola Gomez, H Webster… - Nature …, 2021 - nature.com
Inflammation generally leads to recruitment of monocyte-derived macrophages. What
regulates the fate of these cells and to what extent they can assume the identity and function of …
regulates the fate of these cells and to what extent they can assume the identity and function of …
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
…, DA Gibson, NJ Steers, K Boufea, PA Louwe… - Science …, 2020 - science.org
Macrophages reside in the body cavities where they maintain serosal homeostasis and
provide immune surveillance. Peritoneal macrophages are implicated in the etiology of …
provide immune surveillance. Peritoneal macrophages are implicated in the etiology of …
[HTML][HTML] Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system
CSF1 is the primary growth factor controlling macrophage numbers, but whether expression
of the CSF1 receptor differs between discrete populations of mononuclear phagocytes …
of the CSF1 receptor differs between discrete populations of mononuclear phagocytes …
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum
PA Louwe, SJ Forbes, C Bénézech, C Pridans… - …, 2022 - Wiley Online Library
The relationship between macrophages of the peritoneal cavity and the adjacent omentum
remains poorly understood. Here, we describe two populations of omental macrophages …
remains poorly understood. Here, we describe two populations of omental macrophages …
CD11c identifies microbiota and EGR2‐dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice
CC Bain, PA Louwe, NJ Steers… - European journal of …, 2022 - Wiley Online Library
The murine serous cavities contain a rare and enigmatic population of short‐lived F4/80 lo
MHCII + macrophages but what regulates their development, survival, and fate is unclear. …
MHCII + macrophages but what regulates their development, survival, and fate is unclear. …
Welcoming c-MAF to the macrophage transcription factor VAM-ily
PA Louwe, CL Scott - Science Immunology, 2021 - science.org
The transcription factor c-MAF regulates perivascular macrophage phenotypes across
tissues, including white adipose tissue, where its loss from murine vasculature–associated …
tissues, including white adipose tissue, where its loss from murine vasculature–associated …
Macrophage superclusters to the rescue
PA Louwe, M Guilliams - Science, 2023 - science.org
Positioned at the interface between intestinal and systemic circulation, the liver protects
against blood-borne infections ( 1 , 2 ). To do this, the liver uses a dense network of sinusoids—…
against blood-borne infections ( 1 , 2 ). To do this, the liver uses a dense network of sinusoids—…
Studying Macrophages in the Murine Steatotic Liver Using Flow Cytometry and Confocal Microscopy
Z Liu, PA Louwe, CL Scott - Tissue-Resident Macrophages: Methods and …, 2023 - Springer
The study of macrophage functions in the context of metabolic dysfunction-associated steatotic
liver disease (MASLD) and metabolic dysfunction associated steatohepatitis (MASH) has …
liver disease (MASLD) and metabolic dysfunction associated steatohepatitis (MASH) has …
[HTML][HTML] Systemic influences of mammary cancer on monocytes in mice
Simple Summary Using a mouse model of breast cancer driven by the mammary epithelial
expression of the polyoma middle T oncoprotein in which the tumors progress from benign to …
expression of the polyoma middle T oncoprotein in which the tumors progress from benign to …