Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor …

Depression and posttraumatic stress disorder are assumed to be maladaptive responses to
stress and antidepressants are thought to counteract such responses by increasing BDNF (…

Cannabidiol (CBD) is a major nonpsychotomimetic component of Cannabis sativa that has
been shown to have an anxiolytic effect in human and animal models. Earlier studies suggest …

The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating
anxiety-and panic-related responses. Given the cellular and behavioral evidence suggesting …

Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

The present study was designed to assess the effect of dexamethasone, a synthetic
glucocorticoid receptor agonist, in the sucrose preference test in rats. Rats treated acutely with …

Cannabidiol ( CBD ), one of the main components of C annabis sp., presents clinical and
preclinical anxiolytic properties. Recent results using the marble‐burying test ( MBT ) suggest …

Obsessive–compulsive disorder (OCD) is a common psychiatric disorder characterized by
the occurrence of obsessions and compulsions. Glutamatergic abnormalities have been …

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate
proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV + ) …