Transcriptional silencing of the sex chromosomes during male meiosis (MSCI) is conserved
among organisms with limited sex chromosome synapsis, including mammals. Since the …

Intragenomic conflicts arise when a genetic element favours its own transmission to the
detriment of others. Conflicts over sex chromosome transmission are expected to have …

Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific
region (MSYq) encodes information required for sperm differentiation and postmeiotic sex …

Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths
in women. Here we present an integrated multi-omic analysis of 643 cervical squamous …

We have generated an improved assembly and gene annotation of the pig X Chromosome,
and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones …

Deletions on the mouse Y-chromosome long arm (MSYq) lead to teratozoospermia and in
severe cases to infertility. We find that the downstream transcriptional changes in the testis …

Animals are essential genetic tools in scientific research and global resources in agriculture.
In both arenas, a single sex is often required in surplus. The ethical and financial burden of …

The mouse sex chromosomes exhibit an extraordinary level of copy number amplification of
postmeiotically expressed genes [1, 2], driven by an "arms race" (genomic conflict) between …

… PJI Ellis was funded by the BBSRC (grant number BB/F007434/1). Y Yu and S Zhang
were supported by Chinese projects (S2010GR0947, 2010DFA31820, 2009ZX08009142B, …

Chromosome folding has profound impacts on gene regulation, whose evolutionary
consequences are far from being understood. Here we explore the relationship between 3D …