A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

With an ever-increasing amount of (meta)genomic data being deposited in sequence databases,
(meta)genome mining for natural product biosynthetic pathways occupies a critical role …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

Rapid increases of energy consumption and human dependency on fossil fuels have led to
the accumulation of greenhouse gases and consequently, climate change. As such, major …

Cyclopropane-functionalized hydrocarbons are excellent fuels due their high energy density.
However, the organic synthesis of these molecules is challenging. In this work, we …

Biosynthesis is an environmentally benign and renewable approach that can be used to
produce a broad range of natural and, in some cases, new-to-nature products. However, …

The complete genome sequence of the original isolate of the model actinomycete
Streptomyces lividans 66, also referred to as 1326, was deciphered after a combination of next-…

Natural products from microbes have provided humans with beneficial antibiotics for millennia.
However, a decline in the pace of antibiotic discovery exerts pressure on human health …

Clostridium is a large genus of obligate anaerobes belonging to the Firmicutes phylum of
bacteria, most of which have a Gram-positive cell wall structure. The genus includes significant …

With its ability to catabolize a wide variety of carbon sources and a growing engineering
toolkit, Pseudomonas putida KT2440 is emerging as an important chassis organism for …