Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of
embryonic cells. Transitory pluripotent cells can be captured at different time points during …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency continuum
in vivo. Previous studies have generated a number of PSCs with distinct properties. To date…

The identification of genes and deduced pathways from the mature human oocyte can help
us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. …

Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming following
somatic cell nuclear transfer (SCNT), and may underlie the observed reduced viability of …

Over the last 20-80 million years the mammalian placenta has taken on a variety of morphologies
through both divergent and convergent evolution. Recently we have shown that the …

Background Human induced pluripotent stem cells (IPSCs) have enormous potential in the
development of cellular models of human disease and represent a potential source of …

DNA methylation can be considered a component of epigenetic memory with a critical role
during embryo development, and which undergoes dramatic reprogramming after fertilization. …

POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable
roles in early embryo development and cell lineage specification. The role of embryonic …

One of the ultimate goals of regenerative medicine is the generation of patient-specific organs
from pluripotent stem cells (PSCs). Sheep are potential hosts for growing human organs …

Oocyte developmental competence is the ability of the mature oocyte to be fertilized and
subsequently drive early embryo development. Developmental competence is acquired by …