The forcing that environmental variation exerts on populations causes continuous changes
with only two possible evolutionary outcomes: adaptation or extinction. Here we address this …

The optimization of genetically engineered biological constructs is a key step to deliver high-impact
biotechnological applications. The use of high-throughput DNA assembly methods …

Bacterial gene expression depends on the allocation of limited transcriptional resources
provided a particular growth rate and growth condition. Early studies in a few genes suggested …

The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one
hand, it is necessary to identify which molecular properties are directly altered by the mutation…

Phenotype prediction is at the center of many questions in biology. Prediction is often
achieved by determining statistical associations between genetic and phenotypic variation, …

The ecological role of microorganisms is of utmost importance due to their multiple
interactions with the environment. However, assessing the contribution of individual taxonomic …

The duration of immunity to SARS-CoV-2 is uncertain. Delineating immune memory typically
requires longitudinal serological studies that track antibody prevalence in the same cohort …

The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one
hand, it is necessary to identify which molecular properties are directly altered by the mutation…

The duration of immunity to SARS-CoV-2 is uncertain. Delineating immune memory typically
requires longitudinal serological studies that track antibody prevalence in the same cohort …

… Pablo Yubero, 1 Susanna Manrubia, 1, 2 and Jacobo Aguirre corresponding author 1, 2 …