As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity
and substantial population structure. Importantly, African genomes are heterogeneous: …

Background Genome-wide association studies do not always replicate well across populations,
limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and …

This study presents an Africa-specific genotyping array, which enables investigators to identify
novel disease associations and to fine-map genetic loci that are associated with prostate …

Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan
Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually …

Access to clean water, one of the United Nation’s Sustainable Development Goals, is
challenged by an increase in the presence of emerging microbial and other contaminants due to …

Androgenetic alopecia is a highly heritable trait. However, much of our understanding about
the genetics of male pattern baldness comes from individuals of European descent. Here, …

Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates,
yet the genetic basis of CaP in African men has been understudied. We used genomic data …

… I, Paidamoyo Kachambwa, hereby declare that the work on which this dissertation is based
on my original work (except where acknowledgements indicate otherwise) and that neither …

Prostate cancer is a highly heritable disease that disproportionally affects African and
African-American men. With this in mind, the MADCaP (Men of African Descent Carcinoma of the …

… In fact, fifty years later, the late Leon had a granddaughter, Paidamoyo Neddy Mutyambizi, …
The kids would occasionally and temporarily be housed at Uncle Kachambwa’s house in …