CD4 + type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in
promoting and maintaining tolerance. The absence of surface markers that uniquely identify …

Background Genomewide association studies of autoimmune diseases have mapped hundreds
of susceptibility regions in the genome. However, only for a few association signals has …

Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by
hamartomatous neurological lesions that exhibit abnormal cell proliferation and differentiation. …

We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P < 1.28 × 10 −11 ) independent association …

Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial,
prognostic marker of human glioblastoma multiforme (GBM). However, its functional role …

Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

Benzene is a human carcinogen and an ubiquitous environmental pollutant. Identification of
specific and sensitive biological markers is critical for the definition of exposure to low …

Methods for multiple-testing correction in local expression quantitative trait locus (cis-eQTL)
studies are a trade-off between statistical power and computational efficiency. Bonferroni …

Idiopathic pulmonary fibrosis (IPF) is a complex disease in which a multitude of proteins and
networks are disrupted. Interrogation of the transcriptome through RNA sequencing (RNA-…

Nine polycyclic aromatic hydrocarbons (PAHs) were analysed in pine needles of different
ages (from 6 to 30 months) collected from two species, Pinus nigra and Pinus pinaster, in …