Proteolysis-targeting chimaeras (PROTACs) are molecules that combine a target-binding
warhead with an E3 ligase-recruiting moiety; by drawing the target protein into a ternary …

To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV)
fever. Hence, it is essential to identify drug candidates that could potentially impede …

The sesquiterpenoid juvenile hormone (JH) is vital to insect development and reproduction.
Intracellular JH receptors have recently been established as basic helix-loop-helix …

Janus kinase 2 (JAK2) plays a crucial role in the patho-mechanism of cardiovascular
pathologies, myeloproliferative disorders and many other diseases. Thus, effective JAK2 kinase …

Tankyrase 1 and 2 (TNKS) are promising and attractive therapeutic targets in anticancer
drug development. Herein, we report the findings of structure- and ligand-based virtual …

Tankyrases (TNKS) belong to the poly(ADP-ribose)polymerase (PARP) protein super family
and play a vital role in the Wnt/β-catenin signaling pathway. TNKS is a potential target for …

Over expression of T-lymphokine–activated killer cell–originated protein kinase (TOPK) has
been associated with leukemia, myeloma tumors and various other cancers. The function …

We tested the role of substituents at the C3′ and C3′N positions of the taxane molecule
to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. …

Glioblastoma multiforme (GBM) is considered to be the most common and often deadly
disorder which affects the brain. It is caused by the over expression of proteins such as ephrin …

In this study, a 5-point pharmacophore model was developed and the model was used to
generate a predictive atom-based 3D quantitative structure activity relationship (3D-QSAR) …