In light of the current COVID-19 pandemic, there is an urgent need to accurately infer the
evolutionary and transmission history of the virus to inform real-time outbreak management, …

Despite insights gained by bulk DNA sequencing of cancer it remains challenging to
resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high-throughput …

Monitoring the prevalence of SARS-CoV-2 variants is necessary to make informed public
health decisions during the COVID-19 pandemic. PCR assays have received global attention, …

A tumor contains a diverse collection of somatic mutations that reflect its past evolutionary
history and that range in scale from single nucleotide variants (SNVs) to large-scale copy-…

Motivation While single-cell DNA sequencing (scDNA-seq) has enabled the study of intratumor
heterogeneity at an unprecedented resolution, current technologies are error-prone and …

Optimal sensor placement for fluid flows is an important and challenging problem. In this
study, we propose a completely data-driven and computationally efficient method for sensor …

CRISPR-Cas9-based genome editing combined with single-cell sequencing enables the
tracing of the history of cell divisions, or cellular lineage, in tissues and whole organisms. …

Genes in SARS-CoV-2 and other viruses in the order of Nidovirales are expressed by a
process of discontinuous transcription which is distinct from alternative splicing in eukaryotes …

Background Every tumor is composed of heterogeneous clones, each corresponding to a
distinct subpopulation of cells that accumulated different types of somatic mutations, ranging …

Motivation The combination of genomic and epidemiological data holds the potential to
enable accurate pathogen transmission history inference. However, the inference of outbreak …