The endogenous mechanism that determines vertebrate body length is unknown but must
involve loss of chordo-neural-hinge (CNH)/axial stem cells and mesoderm progenitors in the …

RNA interference (RNAi) provides an effective method to silence gene expression and
investigate gene function. However, RNAi tools for the chicken embryo have largely been …

During early vertebrate development Fibroblast Growth Factor (FGF) signalling is required
for multiple activities including specification of mesodermal, neural and heart tissue, as well …

Here, we exploit the spatial separation of temporal events of neural differentiation in the
elongating chick body axis to provide the first analysis of transcriptome change in progressively …

The vertebrate body forms by continuous generation of new tissue from progenitors at the
posterior end of the embryo. The study of these axial progenitors has proved to be challenging …

Changes in higher order chromatin organisation have been linked to transcriptional
regulation; however, little is known about how such organisation alters during embryonic …

Generation of the spinal cord relies on proliferation of undifferentiated cells located in a caudal
stem zone. Although fibroblast growth factor (FGF) signaling is required to maintain this …

Amino acids are essential for cellular metabolism, and it is important to understand how nutrient
supply is coordinated with changing energy requirements during embryogenesis. Here, …

Species-specific differentiation pace in vitro indicates that some aspects of neural differentiation
are governed by cell intrinsic properties. Here we describe a novel in vitro human neural-…

Dynamic contacts between cells within the developing neuroepithelium are poorly understood
but play important roles in cell and tissue morphology and cell signalling. Here, using live-…