Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and
are required for signaling by the TGFβ superfamily have been poorly defined. The …

We describe Trans-ABySS, a de novo short-read transcriptome assembly and analysis
pipeline that addresses variation in local read densities by assembling read substrings with …

MAD-related (MADR) proteins are essential intracellular components of TGFβ signaling
pathways and are regulated by phosphorylation. Here, we demonstrate that MADR2 and not the …

BMP7 and activin are members of the transforming growth factor β superfamily. Here we
characterize endogenous activin and BMP7 signaling pathways in P19 embryonic carcinoma …

We identify a mammalian forkhead domain protein, FAST2, that is required for induction of
the goosecoid (gsc) promoter by TGFβ or activin signaling. FAST2 binds to a sequence in the …

Smad proteins transmit TGFβ signals from the cell surface to the nucleus. Here we analyze
Smad2 mutant embryos created using ES cell technology. Smad2 function is not required for …

Snail family proteins are key regulators of epithelial-mesenchymal transition, but their role in
endothelial-to-mesenchymal transition (EMT) is less well studied. We show that Slug, a …

HSCs differ during ontogeny in some important parameters, including anatomic site of residence
and cell cycling characteristics. In this issue of the JCI, Bowie et al. show that postnatal …

Various studies have identified a critical role for Notch signaling in cardiovascular development.
In this and other systems, Notch receptors and ligands are expressed in regions that …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-cell
transcriptomes, which represent all endoderm populations within the mouse embryo …