Parkinson's disease (PD), an adult neurodegenerative disorder, has been clinically linked
to the lysosomal storage disorder Gaucher disease (GD), but the mechanistic connection is …

The sirtuins are members of the histone deacetylase family of proteins that participate in a
variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (…

Background Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of
sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with …

Aggregation and cytotoxicity of misfolded α-synuclein is postulated to be crucial in the
disease process of neurodegenerative disorders such as Parkinson's disease and DLB (dementia …

Accumulation of amyloid-β (Aβ) into senile plaques in Alzheimer's disease (AD) is a hallmark
neuropathological feature of the disorder, which likely contributes to alterations in neuronal …

Background Misfolding, oligomerization, and fibrillization of α-synuclein are thought to be
central events in the onset and progression of Parkinson's disease (PD) and related disorders. …

Because accumulation of α-synuclein (αS) in the brain is a hallmark of Parkinson disease (PD)
and related disorders, we examined its occurrence in human cerebrospinal fluid (CSF). …

… Correspondence should be addressed to either of the following: Pamela J. McLean,
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard …

TorsinA, a protein with homology to yeast heat shock protein104, has previously been
demonstrated to colocalize with α‐synuclein in Lewy bodies, the pathological hallmark of …

α-Synuclein is a major component of Lewy bodies, the pathological hallmark of Parkinson
disease, dementia with Lewy bodies, and related disorders. Misfolding and aggregation of α-…