Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue
growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive …

The Hippo signaling pathway is an evolutionarily conserved mechanism that controls organ
size in animals. Yorkie is well known as a transcriptional co-activator that functions …

The engulfment of apoptotic cells is required for normal metazoan development and tissue
remodeling. In Caenorhabditis elegans , two parallel and partially redundant conserved …

Ena/VASP proteins mediate the effects of guidance cues on the actin cytoskeleton. The
single C. elegans homolog of the Ena/VASP family of proteins, UNC-34, is required for the …

Neuropeptide α‐amidation is a common C‐terminal modification of secretory peptides,
frequently required for biological activity. In mammals, amidation is catalyzed by the sequential …

Whereas many molecules that promote cell and axonal growth cone migrations have been
identified, few are known to inhibit these processes. In genetic screens designed to identify …

Synapses are highly specialized for neurotransmitter signaling, yet activity-dependent
growth factor release also plays critical roles at synapses. While efficient neurotransmitter …

The coordinated growth and development of synapses is critical for all aspects of neural
circuit function and mutations that disrupt these processes can result in various neurological …

The Hippo signaling pathway regulates tissue growth and organ development in many animals,
including humans. Pathway activity leads to inactivation of Yorkie (Yki), a transcriptional …

Synapses are highly specialized for neurotransmitter signaling, yet activity-dependent
growth factor release also plays critical roles at synapses. While efficient neurotransmitter …