Despite decades of research, brain tumours remain among the deadliest of all forms of cancer.
The ability of these tumours to resist almost all conventional and novel treatments relates, …

The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid malignancies
such as chronic lymphocytic leukemia (CLL), T-prolymphocytic leukemia (T-PLL), and …

The COVID‐19 pandemic is one of the most serious global challenges to delivering affordable
and equitable treatment to children with cancer we have witnessed in the last few decades…

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and
children, yet significant numbers of patients relapse and die of disease. In this study, we identify …

Background Children with cancer are frequently immunocompromised. While children are
generally thought to be at less risk of severe SARS-CoV-2 infection than adults, …

Optimization of therapy for childhood acute lymphoblastic leukemia (ALL) requires a greater
understanding of the cells that proliferate to maintain this malignancy because a significant …

A significant proportion of children with T-cell acute lymphoblastic leukemia (T-ALL) continue
to fail therapy. Consequently, characterization of the cells that proliferate to maintain the …

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers
which have not benefited from advances made by the international paediatric oncology …

SARS-COV-2 vaccines have been shown to be efficacious primarily in healthy volunteer
populations and population level studies. Immune responses following SARS-CoV-2 …

Background Dysregulated inflammation is associated with poor outcomes in COVID-19. We
aimed to assess the efficacy of namilumab (a granulocyte-macrophage colony stimulating …