Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

Obesity is currently a serious worldwide public health problem, reaching pandemic levels.
For decades, dietary and behavioral approaches have failed to prevent this disease from …

Obesity-associated health complications are thought to be in part due to the low-grade
proinflammatory state that characterizes this disease. The calcium sensing receptor (CaSR), …

Niemann–Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized
by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and …

Excess dietary sucrose is associated with obesity and metabolic diseases. This relationship
is driven by the malfunction of several cell types and tissues critical for the regulation of …

Introduction The modern food environment facilitates excessive calorie intake, a major driver
of obesity. Glucagon-like peptide 1 (GLP1) is a neuroendocrine peptide that has been the …

Obesity is a major worldwide problem, despite considerable efforts against it. While excess
body fat defines obesity, adipose tissue quality and functionality are key to whether …

Obesity, a condition most commonly associated with hyper-leptinemia, is also characterized
by increased expression of autophagy genes and likely autophagic activity in human …

Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that
activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines …

Obesity is a major current public health problem worldwide due to the severe co-morbid
conditions that this disease entails. The development of obesity-related cardiometabolic …