A pathologic expansion of a noncoding GGGGCC hexanucleotide repeat of the C9orf72
gene has been strongly associated with familial amyotrophic lateral sclerosis (ALS) and …

Cognitive impairment is highly prevalent in patients with Parkinson’s disease (PD) and causes
adverse health outcomes. Novel procognitive therapies are needed to address this unmet …

Recent findings of morphological and functional changes in Parkinson’s disease brains have
shown altered synapse formation, but their role in cognitive decline is still an area under …

Background Alteration in glycosphingolipids (GSLs) in Parkinson's disease (PD) still needs
to be determined. Objectives We evaluated if PD subjects show abnormal GSLs levels …

Parkinson’s disease is characterized by a gradual loss of dopaminergic neurons, which is
associated with altered neuronal activity in the beta-band (13–30 Hz). Assessing beta-band …

Background: Visual and oculomotor problems are very common in Parkinson’s disease (PD)
and by using eye-tracking such problems could be characterized in more detail. However, …

Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial
component in motor function is the integration of afferent proprioceptive sensory feedback. …

Previous studies provide partly contradictory results about the characteristics of saccades in
PD and the possible effects of levodopa, which may be attributed to different study design …

Background Cognitive impairment is common in patients with PD. Core markers of Alzheimer's
dementia have been related also to PD dementia, but no disease‐specific signature to …

Background IRL752 is a novel small‐molecule compound that acts to regioselectively enhance
norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex. …