Toward development of a precision medicine framework for metastatic, castration-resistant
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …

Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …

Metastasis is the primary cause of cancer-related deaths. Although The Cancer Genome
Atlas has sequenced primary tumour types obtained from surgical resections, much less …

Through a prospective clinical sequencing program for advanced cancers, four index cases
were identified which harbor gene rearrangements of FGFR2, including patients with …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and …

Programmed death-1 ligand (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1)
pathway blockade is a promising therapy for treating cancer. However, the mechanistic …

Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC)
samples, we identified a novel subtype of prostate cancer typified by biallelic loss of …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of histomorphologies,
proteogenomic alterations, immune cell infiltration patterns, and clinical behavior. …

Importance Cancer is caused by a diverse array of somatic and germline genomic aberrations.
Advances in genomic sequencing technologies have improved the ability to detect these …