An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents
associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to …

The contribution of RNA processing to tumorigenesis is understudied. Here, we report that
the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces …

BAF chromatin remodeling complexes play important roles in chromatin regulation and
cancer. Here, we report that Ewing sarcoma cells are dependent on the autocrine signaling …

Ewing sarcoma is an aggressive cancer of bone and soft tissue in children. It is characterized
by the chromosomal translocation between EWS and an Ets family transcription factor, …

Chemoprevention through dietary intervention is an emerging option to reduce colon
cancer mortality. β-catenin plays an important role in the Wnt signaling cascade that is most …

We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6),
a member of the bone morphogenetic protein (BMP) family of cytokines, maintains …

Fanconi Anemia (FA) complementation group D2 protein (FANCD2) is the center of the FA
tumor suppressor pathway, which has become an important field of investigation in human …

Mutations in the human RecQ helicase, BLM, causes Bloom Syndrome, which is a rare
autosomal recessive disorder and characterized by genomic instability and an increased risk of …

Growing evidence supports a general hypothesis that aging and cancer are diseases related
to energy metabolism. However, the involvement of Fanconi Anemia (FA) signaling, a …

Ewing sarcoma is a cancer of bone and soft tissue in children driven by EWS:: ETS fusion,
most commonly EWS:: FLI1. Because current cytotoxic chemotherapies are not improving the …