Multiple genetic and epigenetic events, including the aberrant expression and function of
molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle …

The aberrant growth of head and neck squamous cell carcinoma (HNSCC) is often associated
with the constitutive activation of signal-transducer-and-activator-of-transcription-3 (STAT3…

Tissue remodeling processes critically depend on the timely removal and remodeling of
preexisting collagen scaffolds. Nevertheless, many aspects related to the turnover of this …

Numerous cell surface receptors, including tyrosine kinase and G protein‐coupled receptors,
play critical roles in endothelial cell function and blood vessel development. These …

Purpose: As an approach to evaluate the expression pattern and status of activation of
signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) …

Emerging knowledge on how the dysregulated function of signaling networks contributes to
the malignant growth of squamous cell carcinoma of the head and neck (HNSCC) can now …

Squamous carcinomas of the head and neck (HNSCC) represent the sixth most common
cancer among men worldwide and a major cause of morbidity and mortality due to its relatively …

Histamine-induced vascular leakage is an integral component of many highly prevalent
human diseases, including allergies, asthma and anaphylaxis. Yet, how histamine induces the …

Tumor cells can co-opt the promigratory activity of chemokines and their cognate G protein–coupled
receptors (GPCRs) to metastasize to regional lymph nodes or distant organs. Indeed…

Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through
a single-pass transmembrane receptor, plexin D1, to provide a repulsive cue for plexin D1-…