The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis
of Alzheimer's disease (AD) ( Walsh and Selkoe, 2007 ). Data from AD brain ( Shankar …

Aggregation of the amyloid Aβ peptide and its accumulation into insoluble deposits (plaques)
are believed to be the main cause of neuronal dysfunction associated with Alzheimer's …

The inhibition of amyloid formation is a promising therapeutic approach for the treatment of
neurodegenerative diseases. Peptide‐based inhibitors, which have been widely investigated…

Saccharomyces cerevisiae Tel1 is the ortholog of human ATM kinase and initiates a cell
cycle checkpoint in response to dsDNA breaks (DSBs). Tel1 ATM kinase is activated …

Nickel(II) complexes of the peptide fragments of human prion protein containing histidyl
residues both inside and outside the octarepeat domain have been studied by the combined …

Protease inhibitor drug discovery is challenged by the lack of cellular and oral permeability,
selectivity, metabolic stability, and rapid clearance of peptides. Here, we describe the …

Nickel(II) complexes of Aβ(1-16)Y10A and its smaller fragments including Aβ(1-4), Aβ(1-6),
Ac-Aβ(1-6) and Ac-Aβ(8-16)Y10A have been studied by potentiometric, UV-Vis and circular …

The fragments of rat amylin rIAPP(17–29) (Ac-VRSSNNLGPVLPP-NH2), rIAPP(17–22) (Ac-VRSSNN-NH2),
rIAPP(19–22) (Ac-SSNN-NH2) and rIAPP(17–20) (Ac-VRSS-NH2) together …

Telomeres are nucleoprotein complexes that protect the ends of chromosomes and are
essential for chromosome stability in Eukaryotes. In cells, individual telomeres form distinct …

Aβ aggregation is a central event in Alzheimer's disease (AD). In vitro evidence indicates
that Aβ aggregation and fibrillogenesis are significantly influenced by the employed …