It has been generally accepted that the mammalian embryo starts its development with all
cells identical, and only when inside and outside cells form do differences between cells first …

Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages. It is
initiated via asymmetric divisions of eight- and 16-cell blastomeres that allocate cells to inner …

To date, many regulatory genes and signalling events coordinating mammalian development
from blastocyst to gastrulation stages have been identified by mutational analyses and …

Setting aside pluripotent cells that give rise to the future body is a central cell fate decision in
mammalian development. It requires that some blastomeres divide asymmetrically to direct …

Endometriosis is a common complex inflammatory condition characterised by the presence
of endometrium-like tissue outside the uterus, mainly in the pelvic area. It is associated with …

Formation of inner and outer cells of the mouse embryo distinguishes pluripotent inner cell
mass (ICM) from differentiating trophectoderm (TE). Carm1, which methylates histone H3R17 …

The relationship between chromatin organization and transcriptional regulation is an area of
intense investigation. We characterized the spatial relationships between alleles of the Oct4…

Advances in genomics are revolutionizing how diseases are prevented, diagnosed, and
treated, across all fields of medicine. In reproductive medicine, genomic technologies are used …

Endometriosis affects ∼10% of women of reproductive age. It is characterized by the growth
of endometrial-like tissue outside the uterus and is frequently associated with severe pain …

Objective To define the landscape of clinically valid genetic associations with IVF treatment
response and outcomes. Design The Clinical Genome (ClinGen) Resource has defined a …