Objectives Silver carbenes may represent novel, broad-spectrum antimicrobial agents that
have low toxicity while providing varying chemistry for targeted applications. Here, the …

Although the potential benefits of gene therapy for the treatment of acquired and inherited
genetic diseases have been demonstrated through preclinical studies, the results of human …

Degradable acetalated dextran (Ac-DEX) nanoparticles were prepared and loaded with a
hydrophobic silver carbene complex (SCC) by a single-emulsion process. The resulting …

Clinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF)
patients, an effect that is currently attributed to ibuprofen's anti-inflammatory properties. Yet, a …

In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle,
capable of carrying silver cations via interactions with alkyne groups, has been developed as a …

Biodegradable segmented l-tyrosine polyurethanes (LTUs) have been developed using a
tyrosine based chain extender desaminotyrosine-tyrosyl-hexyl ester (DTH). Two such …

Silver N-heterocyclic carbene complexes have been shown to have great potential as
antimicrobial agents, affecting a wide spectrum of both Gram-positive and Gram-negative bacteria. …

The use of nebulizable, nanoparticle-based antimicrobial delivery systems can improve
efficacy and reduce toxicity for treatment of multi-drug-resistant bacteria in the chronically …

Pseudomonas aeruginosa has been detected in the lungs of ∼50% of patients with cystic
fibrosis (CF), including 20% of adult CF patients. The majority of these adult patients harbor …

Temperature is an important abiotic factor influencing the survival and fitness of pathogens
as well as their hosts. We investigated the effect of three temperatures (18 C, 27 C and 37 C) …