A chemical probe for dark kinase STK17B derives its potency and high selectivity through a unique P-loop conformation

…, JE Pickett, FE Kwarcinski, P Sinha… - Journal of medicinal …, 2020 - ACS Publications
STK17B is a member of the death-associated protein kinase family and has been genetically
linked to the development of diverse diseases. However, the role of STK17B in normal and …

Identification of 4‐Anilinoquin (az) oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

…, T Laitinen, J Pickett, FE Kwarcinski, P Sinha… - …, 2022 - Wiley Online Library
Deep annotation of a library of 4‐anilinoquin(az)olines led to the identification of 7‐iodo‐N‐(3,4,5‐trimethoxyphenyl)quinolin‐4‐amine
16 as a potent inhibitor (IC 50 =14 nM) of Protein …

Identification and Optimization of cell active 4-anilino-quin (az) oline Inhibitors for Protein Kinase Novel 3 (PKN3)

…, L Temme, T Laitinen, J Pickett, FE Kwarcinski, P Sinha… - bioRxiv, 2020 - biorxiv.org
The development of a small library of 4-anilinoquinolines led to the identification of 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine
16 as a potent inhibitor of Protein Kinase Novel 3 …

[PDF][PDF] Characterization of Phosphogypsum waste for Road construction

V Havanagi, AK Sinha, GS Parvathi - Proceedings of the Indian …, 2018 - researchgate.net
With the large-scale road infrastructural development in the country, natural resources like
soil and aggregates are depleting significantly, increasing tremendously the cost of …

[BOOK][B] Defining the role of secondary DNA structures and transcription factors on the transcriptional control of the HIF-1alpha and VEGF promoters

DJ Uribe - 2011 - search.proquest.com
Angiogenesis is known to be induced and maintained in tumors by the constant expression
of the hypoxia inducible factor 1 alpha (HIF-1α) and human vascular endothelial growth …

Fault Detection and Analysis in embedded SRAM for sub nanometer technology

V Maddela, SK Sinha, M Parvathi… - … Conference on Applied …, 2022 - ieeexplore.ieee.org
Now a day's semiconductor memories are used in every digital system, to store programs and
huge data. so that embedded memories occupy more than 94% of the area on SoC. As the …

Comparative Analysis of Open and Short Defects in Embedded SRAM Using Parasitic Extraction Method for Deep Submicron Technology

V Maddela, SK Sinha, M Parvathi, V Sharma - Wireless Personal …, 2023 - Springer
The technology advances from the micron level to the Nanometer level. This striking change
in the technology with so many factors might influence the embedded device design and its …

Extraction of undetectable faults in 6T-SRAM cell

V Maddela, SK Sinha, M Parvathi - … International Conference on …, 2021 - ieeexplore.ieee.org
As the need to store more information, the density of Static Random-Access Memory (SRAM)
increases, and it occupies more space on System on Chip (SOC), hence it has become …

[PDF][PDF] Open Defect Fault Analysis in Single Cell SRAM Using R, and C Parasitic Extraction Method

V Maddela, SK Sinha, M Parvathi - 2021 - easychair.org
As the technology scaling is increasing, the device density is more prone to parasitic effects
that lead to some form of undetectable faults. However, the existing test methods are not …

Parasitic RC Estimation and Defect Prediction for Embedded Memory using Machine Learning

V Maddela, SK Sinha, M Parvathi, S Chander - 2024 - researchsquare.com
In today's rapidly scaling-down technological environment, identifying the best-fit algorithms
for evaluating complicated circuits such as SRAMs is a difficult issue. Many fault models …