Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

W Kong, J Wei, P Abidi, M Lin, S Inaba, C Li, Y Wang… - Nature medicine, 2004 - nature.com
We identify berberine (BBR), a compound isolated from a Chinese herb, as a new
cholesterol-lowering drug. Oral administration of BBR in 32 hypercholesterolemic patients for 3 …

Extracellular signal-regulated kinase–dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine

P Abidi, Y Zhou, JD Jiang, J Liu - Arteriosclerosis, thrombosis, and …, 2005 - Am Heart Assoc
Objective— Our recent studies identified berberine (BBR) as a novel cholesterol-lowering
drug that upregulates low-density lipoprotein (LDL) receptor expression through mRNA …

Glutathione redox system in oxidative lung injury

Q Rahman, P Abidi, F Afaq, D Schiffmann… - Critical Reviews in …, 1999 - Taylor & Francis
Glutathione (GSH) is a ubiquitous intracellular thiol present in all tissues, including lung.
Besides maintaining cellular integrity by creating a reduced environment, GSH has multiple …

[HTML][HTML] Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements [S]

H Li, W Chen, Y Zhou, P Abidi, O Sharpe… - Journal of lipid …, 2009 - ASBMB
The 3′untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich
elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization …

[HTML][HTML] The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms

P Abidi, W Chen, FB Kraemer, H Li, J Liu - Journal of lipid research, 2006 - ASBMB
Our previous studies have identified berberine (BBR), an alkaloid isolated from the Chinese
herb huanglian, as a unique cholesterol-lowering drug that upregulates hepatic low density …

Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin M reduces hypertriglyceridemia through enhanced β-oxidation

Y Zhou, P Abidi, A Kim, W Chen, TT Huang… - … , and vascular biology, 2007 - Am Heart Assoc
Objective— In our previous studies that examined in vivo activities of oncostatin M (OM) in
upregulation of hepatic LDL receptor (LDLR) expression, we observed reductions of LDL-…

Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway

P Abidi, H Zhang, SM Zaidi, WJ Shen… - Journal of …, 2008 - joe.bioscientifica.com
Previous studies from this laboratory identified excessive oxidative stress as an important
mediator of age-related decline in steroid hormone production. Here, we investigated whether …

[HTML][HTML] Specific interaction of Egr1 and c/EBPβ leads to the transcriptional activation of the human low density lipoprotein receptor gene

F Zhang, M Lin, P Abidi, G Thiel, J Liu - Journal of Biological Chemistry, 2003 - ASBMB
The sterol-independent regulatory element (SIRE) of the LDL receptor (LDLR) promoter
mediates oncostatin M (OM)-induced transcription of the LDLR gene through a cholesterol-…

Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma

…, XE Zhang, TTC Yang, M Liedtke, P Abidi… - Journal of Experimental …, 2022 - rupress.org
Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges
for patients with hematological cancers. Here, we reveal distinctive requirements for …

Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3 and MPL mutations

…, AG Tsai, J Jin, WH Witteles, Z Chen, P Abidi… - Blood …, 2023 - ashpublications.org
Cyclic thrombocytopenia (CTP) is a rare disease of periodic platelet count oscillations. The
pathogenesis of CTP remains elusive. To study the underlying pathophysiology and genetic …