[HTML][HTML] Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome

S Plante, KM Moon, P Lemieux, LJ Foster… - PLoS Biology, 2023 - journals.plos.org
The biophysical properties of the cytoplasm are major determinants of key cellular
processes and adaptation. Many yeasts produce dormant spores that can withstand extreme …

Dissection of the role of a Src homology 3 domain in the evolution of binding preference of paralogous proteins

P Lemieux, D Bradley, AK Dubé, U Dionne… - Genetics, 2024 - academic.oup.com
Protein–protein interactions (PPIs) drive many cellular processes. Some interactions are
directed by Src homology 3 (SH3) domains that bind proline-rich motifs on other proteins. The …

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

S Dibyachintan, AK Dube, D Bradley, P Lemieux… - bioRxiv, 2024 - biorxiv.org
Paralogous genes are often redundant for long periods of time before they diverge in function.
While their functions are preserved, paralogous proteins can accumulate mutations that, …

Exit of spore dormancy transforms the yeast cytoplasm and the solubility of its proteome

S Plante, KM Moon, P Lemieux, LJ Foster, CR Landry - bioRxiv, 2022 - biorxiv.org
The biophysical properties of the cytoplasm are major determinants of key cellular processes
and adaptation. Yeasts produce dormant spores that can withstand extreme conditions. We …

[PDF][PDF] Toeholder: a software for automated design and in silico validation of toehold riboswitches

AF Cisneros, FD Rouleau, C Bautista, P Lemieux… - bioRxiv, 2021 - peerj.com
Synthetic biology aims to engineer biological circuits, which often involve gene expression.
A particularly promising group of regulatory elements are riboswitches because of their …

[HTML][HTML] A novel approach for engineering biological systems by interfacing computer science with synthetic biology

S Melamed - Peer Community in Genomics, 2022 - genomics.peercommunityin.org
A recommendation of: Angel F. Cisneros, François D. Rouleau, Carla Bautista, Pascale
Lemieux, Nathan Dumont-Leblond Toeholder: a Software for Automated Design and In Silico …

Cutting edge: Ly49A inhibits TCR/CD3-induced apoptosis and IL-2 secretion

J Roger, A Chalifour, S Lemieux… - The Journal of …, 2001 - journals.aai.org
To evaluate the importance of Ly49A on TCR-induced cellular events, we established clones
of the 1F2 T cell hybridoma expressing either Ly49A or a chimeric version, Ly49A/H, where …

Helix-length compensation studies reveal the adaptability of the VS ribozyme architecture

J Lacroix-Labonte, N Girard, S Lemieux… - Nucleic acids …, 2012 - academic.oup.com
Compensatory mutations in RNA are generally regarded as those that maintain base pairing,
and their identification forms the basis of phylogenetic predictions of RNA secondary …

Impact of waist circumference on the relationship between blood pressure and insulin: the Quebec Health Survey

P Poirier, I Lemieux, P Mauriege, E Dewailly… - …, 2005 - Am Heart Assoc
Hyperinsulinemia has been suggested to be involved in the etiology of obesity-associated
hypertension. The objective of the present study was to quantify, in a population-based study, …

Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men

…, N Alméras, A Tremblay, I Lemieux… - The Journal of …, 2005 - academic.oup.com
The present study examined the associations between a major adipokine, adiponectin, and
adiposity indices as well as metabolic risk variables in a sample of 190 untreated …