Oxidative stress has been hypothesized to play a role in normal aging. The response to
oxidative stress is regulated by the SKN‐1 transcription factor, which also is necessary for …

Research in aging biology has identified several pathways that are molecularly conserved
across species that extend lifespan when mutated. The insulin/insulin‐like signaling ( IIS ) …

The level of green fluorescent protein expression from an hsp-16.2–based transcriptional
reporter predicts life span and thermotolerance in Caenorhabditis elegans. The initial report …

The genetic analysis of aging processes has matured in the last ten years with reports that
long-lived strains of both fruit flies and nematodes have been developed. Several attempts to …

Many traits vary among isogenic individuals in homogeneous environments. In microbes,
plants and animals, variation in the protein chaperone system affects many such traits. In the …

In multicellular organisms such as Caenorhabditis elegans, differences in complex phenotypes
such as lifespan correlate with the level of expression of particular engineered reporter …

The large post-reproductive life span reported for the free-living hermaphroditic nematode,
Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-…

Genetically identical organisms grown in homogenous environments differ in quantitative
phenotypes. Differences in one such trait, expression of a single biomarker gene, can identify …

Expression level of an hsp-16.2::gfp transgene is a predictor of longevity in Caenorhabditis
elegans. Here we examine fertility, movement and longevity, comparing high-expressing (“…

Animals, particularly poikilotherms, exhibit distinct physiologies at different environmental
temperatures. Here, we hypothesized that temperature-based differences in physiology could …